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Inhibition of Phosphatidylinositol 4-Kinase Results in a Significant Reduced Respiratory Burst in Formyl-methionyl-leucyl-phenylalanine-stimulated Human Neutrophils
2001
Journal of Biological Chemistry
The effects of phenylarsine oxide and a monoclonal antibody directed against type II phosphatidylinositol 4-kinase (PI4K) on the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated respiratory burst and the PI4K activity in neutrophils were investigated. Fluorescence microscopic imaging showed that the antibody labeled with IANBD amide (N,N-dimethyl-N-(iodoacetyl)-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)ethylenediamine) could enter into the cytosol possibly by endocytosis. It was found that
doi:10.1074/jbc.m101328200
pmid:11592957
fatcat:4mjngq3mi5godkvw6cb7wzd6bu