New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Lin-lin Ji, Xin Wang, Jin-jie Li, Xiang-jian Zhong, Bo Zhang, Jing Juan, Xiao-ya Shang
2019 Molecules  
Three previously undescribed iridoids, cornusfurals A–C, were isolated from the ethanolic extracts of fruits of Cornus officinalis. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased
more » ... eased corticosterone-induced PC12 cell damage compared with that in model cells.
doi:10.3390/molecules24030625 fatcat:mqdxp5v7sreqfofq3v25lldsca