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An Inhibitory Region of the DNA-Binding Domain of Thyroid Hormone Receptor Blocks Hormone-Dependent Transactivation
1998
Molecular Endocrinology
We have employed a chimeric receptor system in which we cotransfected yeast GAL4 DNA-binding domain/retinoid X receptor  ligand-binding domain chimeric receptor (GAL4RXR), thyroid hormone receptor- (TR), and upstream activating sequence-reporter plasmids into CV-1 cells to study repression, derepression, and transcriptional activation. In the absence of T 3 , unliganded TR repressed transcription to 20% of basal level, and in the presence of T 3 , liganded TR derepressed transcription to
doi:10.1210/mend.12.1.0046
pmid:9440808
fatcat:iagmsqjlm5bfbn2tu6txwzxo4y