Chromatographic lipophilicity as a predictor of antiproliferative activity of 17-picolyl and 17-picolinylidene androstane derivatives toward prostate cancer

Strahinja Kovacevic, Sanja Podunavac-Kuzmanovic, Lidija Jevric, Evgenija Djurendic, Jovana Ajdukovic, Pavle Jovanov
2015 Acta Periodica Technologica  
The present study describes the quantitative retention -(anticancer) activity relationship analysis of a series of 17-picolyl and 17-picolinylidene androstane derivatives based on the chromatographic data obtained by reversed-phase high performance liquid chromatography (C18-RP-HPLC) in a mobile phase consisting of 90% of methanol and 10% of water. The obtained retention factor or chromatographic lipophilicity factor (logk 0.90 ) was correlated with the antiproliferative activity of studied
more » ... vity of studied compounds (IC 50 ) toward androgen-receptor negative prostate cancer cell line (AR-neg. PC-3). Correlation analysis was carried out by applying non-linear artificial neural networks (ANNs) method. Statistical validation showed that the obtained ANNs can successfully predict the IC 50 values of structurally similar androstane derivatives.
doi:10.2298/apt1546239k fatcat:nmo5fy2kknc3ng5eliottwvc2u