The purpose of this study was to investigate the clinical effect of dentifrice R containing 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the improvement of periodontal disease compared with dentifrice T containing 0.05% tranexamic acid. Subjects were 148 adults who had no serious oral or systemic diseases. They were divided into two groups equally and performed toothbrushing twice a day for four weeks with dentifrice R or T. The PMA index, redness, swelling, and plaque score

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... re selected as indices for clinical evaluation of periodontal condition. The results obtained were as follows. 1) Dentifrice R was significantly superior to dentifrice T in the improvement of PMA index (p<0.01), redness (p<0.01) and swelling (p<0.05). There was no significant difference in the improvement of plaque score between dentifrices R and T. 2) The mean improvement rates of dentifrice R and dentifrice T were 37.0% and 26.3% in PMA index, 40.7% and 25.2% in redness, and 36.7% and 29.9% in swelling, respectively. 3) No particular side effects were observed during this clinical study.