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The acquisition of effective Vpu-mediated anti-tetherin activity distinguishes pandemic HIV-1 group M strains from non-pandemic group N, O and P viruses and may have been a prerequisite for their global spread. Sequence analyses revealed that the motifs in the cytoplasmic tail of Vpu reported to be required for effective antagonism of human tetherin are often conserved in SIVcpzPtt Vpus from Central chimpanzees but usually absent in SIVcpzPts Vpus from Eastern chimpanzees and SIVgor Vpus fromdoi:10.18725/oparu-3436 fatcat:euu6gntmc5fyzgdyugiq7n4ika