SATgenε dietary strategy to investigate the impact of the apo E genotype on LDL-cholesterol response to dietary fat manipulation

S. Lockyer, A. L. Carvalho-Wells, A. M. Minihane, K. G. Jackson, J. A. Lovegrove
2011 Proceedings of the Nutrition Society  
There is emerging evidence that polymorphisms in the gene encoding for apoE impact on the LDL-cholesterol (LDL-C) response to dietary fat intake. It has been reported that carriers of the apoE4 allele have higher plasma LDL-C concentrations after ingestion of saturated fat (SFA) (1) and docosahexanaeoic acid (DHA) ( > 2g/d) (2) compared with the apoE3 wild-type. The aim of the SATgene study was to investigate the impact of a combination of SFA and DHA intake on plasma lipids according to apoE
more » ... according to apoE genotype.
doi:10.1017/s0029665111002606 fatcat:hjruipguxjbdtm3njvd723uccq