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The hematogenous metastases of colon cancer have primarily been explained by the cascade hypothesis based on the cadaveric study. However, we experienced several cases with isolated lung metastasis. The metastatic patterns of a total of 982 patients with colon cancer who underwent surgery were reviewed. The incidence of single-site metastasis in curatively resected cases was significantly higher than in Stage IV cases (P ¼ 0.002). The frequency of liver metastasis was significantly lower indoi:10.1093/jjco/hyt002 pmid:23365110 fatcat:i6czpbo2j5ddfg45ehd2b57bya