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Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins
2018
The FEBS Journal
Recent advances in computational protein design now enable the massively parallel de novo design and experimental characterization of small hyperstable binding proteins with potential therapeutic activity. By providing experimental feedback on tens of thousands of designed proteins, the design-build-test-learn pipeline provides a unique opportunity to systematically improve our understanding of protein folding and binding. Here, we review the structures of mini-protein binders in complex with
doi:10.1111/febs.14394
pmid:29389072
pmcid:PMC6001749
fatcat:sypsjomfmncgnl6jiare3bomji