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Background. Immunoglobulin A nephropathy (IgAN) is the most common cause of chronic renal failure among primary glomerulonephritis patients. The best treatment for IgAN remains poorly defined. We planned a long-term, prospective, open-label, multicentre, centrally randomized controlled trial to assess whether the combination of prednisone and ramipril was more effective than ramipril alone in patients with proteinuric IgAN. C The Author 2009. Published by Oxford University Press [on behalf ofdoi:10.1093/ndt/gfn637 pmid:19028753 fatcat:yqpxempx4zfzbfcylyrgws5kja