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Semantic interoperability is one of the great challenges in biomedical informatics. Methods such as ontology alignment or use of metadata neither scale nor fundamentally alleviate semantic heterogeneity among information sources. In the context of the Cancer Biomedical Informatics Grid program, the Biomedical Research Integrated Domain Group (BRIDG) has been making an ambitious effort to harmonize existing information models for clinical research from a variety of sources and modelingdoi:10.1016/j.jbi.2007.03.004 pmid:17452021 fatcat:toyojd6ggvgbbpl4zc3wgj2pwe