Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006–2011

Kashif Iqbal, R. Monina Klevens, Marion A. Kainer, Jennifer Baumgartner, Kristin Gerard, Tasha Poissant, Kristin Sweet, Candace Vonderwahl, Tracey Knickerbocker, Yury Khudyakov, Guo-liang Xia, Henry Roberts (+1 others)
2015 Clinical Infectious Diseases  
Background. An estimated 20 000 new hepatitis B virus (HBV) infections occur each year in the United States. We describe the results of enhanced surveillance for acute hepatitis B at 7 federally funded sites over a 6-year period. Methods. Health departments in Colorado, Connecticut, Minnesota, Oregon, Tennessee, 34 counties in New York state, and New York City were supported to conduct enhanced, population-based surveillance for acute HBV from 2006 through 2011. Demographic and risk factor data
more » ... nd risk factor data were collected on symptomatic cases using a standardized form. Serum samples from a subset of cases were also obtained for molecular analysis. Results. In the 6-year period, 2220 acute hepatitis B cases were reported from the 7 sites. For all sites combined, the incidence rate of HBV infection declined by 19%, but in Tennessee incidence increased by 90%, mainly among persons of white race/ethnicity and those aged 40-49 years. Of all reported cases, 66.1% were male, 57.1% were white, 58.4% were aged 30-49 years, and 60.1% were born in the United States. The most common risk factor identified was any drug use, notably in Tennessee; healthcare exposure was also frequently reported. The most common genotype for all reported cases was HBV genotype A (82%). Conclusions. Despite an overall decline in HBV infection, attributable to successful vaccination programs, a rise in incident HBV infection related to drug use is an increasing concern in some localities.
doi:10.1093/cid/civ332 pmid:25904365 fatcat:tbkvjve4lnhkplh23b7i5frbgy