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Contemporary neuroscience has embraced network science and dynamical systems to study the complex and self-organized structure of the human brain. Despite the developments in non-invasive neuroimaging techniques, a full understanding of the directed interactions in whole brain networks, referred to as effective connectivity, as well as their role in the emergent brain dynamics is still lacking. The main reason is that estimating brain connectivity requires solving a formidable large-scaledoi:10.1016/j.neuroimage.2019.116367 pmid:31812714 fatcat:qfeo2piy2rhqtbdeenv42igtvm