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Resistance to chemotherapy is a significant barrier to the effective management of prostate cancer. Human pregnane X receptor (hPXR), an orphan nuclear receptor known for its activation by many important clinical drugs, interacts with many cellular signaling pathways during carcinogenesis and is a major transcription factor regulating the expression of drug metabolism enzymes, including transporters.doi:10.1158/0008-5472.can-06-4758 pmid:17974979 fatcat:bm6h7k5ilnd6hnbfq5q5h6gaxq