Aim: to compare surgical stress between (TAH) and (NDVH) in women whom hysterectomy is indicated for benign disease by perioperative inflammatory response using interleukin-6 (IL6) and perioperative clinical outcomes. Patients & Methods: Twenty patients with benign uterine disease and failed medical treatment with uterine size <12 weeks were randomized into two equal group for either TAH or NDVH. Serum levels of IL6 In venous blood were analyzed preoperatively and 3, 24,72 hour after beginning

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... ur after beginning of surgery. Intraoperative, postoperative clinical outcome measure and surgery related morbidity were also, evaluated in both groups. Statistical analysis was done using medcalc software bvba 2016. Results: There was no statistically significant difference present in demographic characteristics, operative duration and uterine weight between TAH and NDVH groups. No major complications were occurred. There was statistically significant increase in serum IL6 level from preoperative value to the 3 hours value after beginning of surgery in TAH group when compared with NDVH group, indicating greater tissue trauma in TAH group. There was statistically significant results in favour of NDVH over TAH as regards hospital stay, pain score, need for analgesia, wound infection, recuperation time (P < 0.05). Conclusion: NDVH is better than TAH for uteri less than 12 weeks in terms of perioperative inflammatory response and clinical outcome measures.