Usefulness of continuous blood glucose monitoring and control for patients undergoing liver transplantation

Tsuyoshi Okada, Shinji Kawahito, Naoji Mita, Munehide Matsuhisa, Hiroshi Kitahata, Mitsuo Shimada, Shuzo Oshita
2013 Journal of Medical Investigation  
: The purpose of this study was to evaluate the usefulness of the closed-loop system (STG-22 ; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose in patients undergoing liver transplantation. Methods : Sixteen patients undergoing livingdonor liver transplantation were enrolled in this study. Glucose levels were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual
more » ... iding scale (manual insulin group, n=8) or a programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n=8). The target glucose level range was set at 80-150 mg/dl. Results : The mean and SD of blood glucose concentration during surgery (Glu-Ave and Glu-SD, respectively) for the programmed insulin group were lower than for the manual insulin group. The coefficient of variability (Glu-CV=Glu-SD 100 /Glu-Ave) for the programmed insulin group was also lower than for the manual insulin group (20.1 4.9% % vs. 26.9 6.1% % ; mean SD). No hypoglycemia was detected in either group. Conclusion : The STG-22 closed-loop system is effective for maintaining strict blood glucose control during liver transplantation with minimal variability in blood glucose concentration. J. Med. Invest. 60 : 205-212, August, 2013
doi:10.2152/jmi.60.205 pmid:24190037 fatcat:v43zh7mwbjdwvdbf2a4tveadiq