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The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole .Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used in the formulation .Invitro release profiles ofdoi:10.22270/jddt.v9i1.2258 fatcat:nw7xr6qfujea7ikhir7qrw6gwe