The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole .Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used in the formulation .Invitro release profiles of

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... optimized form of F6 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. . In vitro release profiles of optimized formulation of Esomeprazole controlled release tablets (F-6) were found to be improvised and followed zero - order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.