Non-alcoholic Fatty Liver Disease and Surgery [chapter]

Monjur Ahmed
2019 Liver Disease and Surgery [Working Title]  
There is an epidemic of nonalcoholic fatty liver disease (NAFLD) paralleling the epidemic of obesity and metabolic syndrome. NAFLD is the most common cause of abnormal liver function test and chronic liver disease in the Western world. NAFLD can progress to nonalcoholic steatohepatitis, cirrhosis of the liver, and hepatocellular carcinoma. Most patients with NAFLD die from cardiovascular disease and malignancy. Medical therapy for NAFLD is not very effective at the present time. Treatment of
more » ... LD starts with weight loss. Bariatric surgery is able to cause significant and sustained weight loss. There are different models of bariatric surgery. Commonly performed ones are Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy, and laparoscopic adjustable gastric banding (LAGB). They can improve steatosis, steatohepatitis, and fibrosis in non-cirrhotic and compensated cirrhotic patients. Each of them has benefits and risks. The bariatric surgical procedures need to be individualized according to the patient's condition. Keywords: nonalcoholic fatty liver disease, bariatric surgery, role of surgery in NAFLD, liver transplantation and NAFLD Liver Disease and Surgery
doi:10.5772/intechopen.86146 fatcat:gqsyosdmfbci7hreehwwpi2mjy