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The intention of the first part of this paper is to present evidence of the safety with non-syphilitic serums and the specificity with syphilitic serums of the cholesterin heart antigen in the Wassermann reaction. The second part of the paper demonstrates that this specificity is due to cholesterin. No attempt will be made to discuss the reasons for this specificity. The work is treated largely from the technical point of view, and thus assumes a general knowledge of the principles and even ofdoi:10.1001/archinte.1914.00070160113009 fatcat:atvthjfivjdtdg3lujknpmqdvi