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Derivation of Huntington disease affected Genea020 human embryonic stem cell line
Stem Cell Research
The Genea020 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying Htt gene CAG expansion of 48 repeats, indicative of Huntington disease. Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XX by CGH and STR analysis demonstrated a female allele pattern. The hESC line had pluripotent cell morphology, 89% of cells expressed Nanog, 95% Oct4, 29% Tra1-60 and 99% SSEA4, gave a Pluritest pluripotency scoredoi:10.1016/j.scr.2016.02.009 pmid:27346007 fatcat:yy2t2al5fjfq3e4v2vj7twl3nm