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Firstly, an SEIR mathematical model with standard incidence rate is established to describe the transmission of Hand-Foot-Mouth disease (HFMD). The equilibrium of the nondimensionalized model is calculated and the basic reproduction number of the model is defined. In addition, the local stability of the equilibrium is analyzed via the characteristic roots of the Jacobian matrix at the equilibrium, respectively. Numerical simulations are given to confirm the theoretical results. Secondly, adoi:10.3390/mca22020029 fatcat:6jwygcrt4vhotow3cwiy6hmwt4