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Meloxicam (MLX), a non-steroidal anti-in‰ammatory drug (NSAID) and a selective COX-2 inhibitor is a water insoluble drug (about 12 mg/ml). In order to improve the aqueous solubility of the drug and its dissolution rate, physical mixture and solid dispersions with skimmed milk were prepared and investigated. Enhancement of aqueous solubility of MLX was observed with solid dispersion of the drug with skimmed milk due to amino acids and surface active agents content in the milk, which can be useddoi:10.1248/yakushi.126.93 pmid:16462098 fatcat:lprbj7xhjjg45pd47bzsk2ixpm