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Synthesis and anticancer evaluation of novel tetrahydronaphthalen-6-ylthiazole heterocycles against human HePG2 and MCF7 cell lines
2010
Der Pharma Chemica
unpublished
A new series of tetrahydronaphthalen-6-ylthiazole derivatives incorporated into/or fused to different five or six membered nitrogen and sulphur containing heterocycles including pyrazoles, triazolothiazoles, thiazolidinones, pyrimidinethione ,thiazolotriazine and/or sulphonamides was synthesized starting from the new 4-(1,2,3.4-tetrahydronaphthalen-6-yl)-2-hydrazinothiazole (2) and/ or the 2-chlorothiazole derivative 18 as synthons. The anticancer activity of eleven of these compounds was
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