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Cu (I)-catalyzed alkyne-azide cycloaddition was carried out for the preparation of novel 1,4-disubstituted 1,2,3-triazoles of D-(+)-pinitol. All the analogs were screened for cytotoxicity against promyelocytic leukemia (HL-60), colorectal carcinoma (HCT 116) and pancreatic carcinoma (Mia-Paca-2) cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay. Compounds 2, 3 and 7 showed the best activity with IC 50 of 19.2, 17.5 and 16.4 lM againstdoi:10.1016/j.arabjc.2015.10.009 fatcat:qyz6nwqv4vgsfjcx3llzyx27ju