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Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice
2012
The contribution of NLRP3, a member of the nucleotide-binding domain leucine-rich repeat containing (NLR) family, in the development of allergic airway disease is currently controversial. Here, we used multiple allergic asthma models to examine the physiologic role of NLRP3. We found no significant differences in airway eosinophilia, histopathology, mucus production and airway hyperreactivity between wild type and Nlrp3-/- mice in either acute (alum-dependent) or chronic (alum-independent) OVA
doi:10.17615/n36e-cj27
fatcat:poqwfkl3erfsva73rcsg5rbo2m