Distribution of 125I-labeled [2-8]-leucopyrokinin, active analog of leucopyrokinin in rats

Andrzej Plech, Monika Rykaczewska-Czerwińska, Florian Ryszka, Aleksandra Suszka-Switek, Barbara Dolińska, Danuta Konopińska
Acta Poloniae Pharmaceutica - Drug Research  
The brain and internal organs distribution of 125I-labeled [2-8]-leucopyrokinin ([2-8]-LPK), a truncated analog of leucopyrokinin (LPK), an insect myotropic peptide injected into the lateral brain ventricle was determined in rats. A high accumulation of this analog in adrenals and in the hypothalamus and hippocampus of the brain was found. A lesser but significant [2-8]-LPK accumulation in other internal organs and parts of the brain was also observed. The results of the present study confirm
more » ... sults of our previous study performed on the distribution of labeled native LPK in rats. A possible significance of obtained results for the brain function was discussed.
pmid:16459488 fatcat:v4cvinvk7bcazmfuwd4tn4zdla