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Quantitative magnetic resonance (MR) imaging allows visualization of agerelated changes in the normal human brain from functional, biochemical, and morphologic perspectives. Findings at quantitative MR imaging support age-related microstructural changes in the brain: (a) volume expansion, increased myelination, and axonal growth, which establish neural connectivity in neurodevelopment, followed by (b) volume loss, myelin breakdown, and axonal degradation, leading to the disruption of neuraldoi:10.1148/rg.335125212 pmid:24025926 fatcat:hgtngzel2bhwlj2aicccyl64sq