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Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice

Vadivel Parthsarathy, Chris M. McLaughlin, Shaun J. Sharkey, Pádraigín A. Harnedy-Rothwell, Ryan A. Lafferty, Philip J. Allsopp, Emeir M. McSorley, Richard J. Fitzgerald, Finbarr P.M. O'Harte
2021 Journal of food bioactives : an official scientific publication of the International Society of Nutraceuticals and Functional Foods (ISNFF)  

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There is increasing interest in dietary protein for management of Type 2 diabetes mellitus (T2DM) and obesity. The effects of twice-daily oral administration of a salmon skin gelatin hydrolysate (SSGH, 50 mg/kg), boarfish protein hydrolysate (BPH, (50 mg/kg), metformin (200 mg/kg), or saline control, were investigated in ob/ob mice. Non-fasting blood glucose was significantly reduced with SSGH (p<0.01), BPH (p<0.001) and metformin (p<0.001), which were reflected in reductions in glycated
more » ... obin (HbA1c) (p<0.001, p<0.01 and p<0.01, respectively). Responses to oral and intraperitoneal glucose tolerance were improved (p<0.05-0.01), as well as circulating plasma lipid profiles (p<0.05-0.001). Chronic BPH treatment increased circulating plasma insulin (p<0.01), whereas SSGH improved insulin sensitivity (p<0.05), versus respective controls. All treatments significantly reduced energy intake (p<0.05-<0.001) versus (ob/ob) controls, without affecting overall bodyweight. These findings suggest that fish hydrolysates mediate potent anti-diabetic actions similar to metformin and might be suitable for the management and prevention of T2DM.
doi:10.31665/jfb.2021.16292 fatcat:tsqaal4gdfecrdp7uh5bag55mq
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Vadivel Parthsarathy, Chris M. McLaughlin, Shaun J. Sharkey, Pádraigín A. Harnedy-Rothwell, Ryan A. Lafferty, Philip J. Allsopp, Emeir M. McSorley, Richard J. Fitzgerald, Finbarr P.M. O'Harte. "Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice." Journal of food bioactives : an official scientific publication of the International Society of Nutraceuticals and Functional Foods (ISNFF) (2021)