t(5;12)(q33;p13) ATF7IP/PDGFRB

Kenichiro Kobayashi
2017 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Ph-like ALL is characterized by several chromosomal translocations involving activating cytokine receptor or tyrosine kinase such as CRLF2, ABL1, JAK2, and PDGFRB (Robert K.G et al, 2014). Recent increasing evidences suggest that patients with Ph-like ALL bearing PDGFRB translocation are potentiated to respond to tyrosine kinase inhibitors. Thus, this translocation should be included within the molecular companion diagnostics to facilitate tailor-made cancer therapy. Keywords Ph-like acute
more » ... oblastic leukemia, tyrosine kinase inhibitor (TKI), PDGFRB
doi:10.4267/2042/62263 fatcat:45uajlkm2reexkrndd5lgpeyry