Graphene FET Array Biosensor Based on ssDNA Aptamer for Ultrasensitive Hg2+ Detection in Environmental Pollutants

Jiawei Tu, Ying Gan, Tao Liang, Qiongwen Hu, Qian Wang, Tianling Ren, Qiyong Sun, Hao Wan, Ping Wang
2018 Frontiers in Chemistry  
Invisible mercury ion is an extremely poisonous environmental pollutant, therefore, a fast and highly sensitive detection method is of significant importance. In this study, a liquid-gated graphene field-effect transistor (GFET) array biosensor (6 × 6 GFETs on the chip) was fabricated and applied for Hg 2+ quantitate detection based on single-stranded DNA (ssDNA) aptamer. The biosensor showed outstanding selectivity to Hg 2+ in mixed solutions containing various metal ions. Moreover, the
more » ... oreover, the sensing capability of the biosensor was demonstrated by real-time responses and showed a fairly low detection limit of 40 pM, a wide detection ranged from 100 pM to 100 nM and rapid response time below one second. These results suggest that the GFET array biosensor based on ssDNA aptamer offers a simple fabrication procedure and quite fast method for mercury ion contaminant detection and are promising for various analytical applications.
doi:10.3389/fchem.2018.00333 pmid:30155458 fatcat:ufxem5cacfgilm3ykwezexhbzi