In vitro antiplasmodial activity of PDDS-coated metal oxide nanoparticles against Plasmodium falciparum

Samuel Jacob Inbaneson, Sundaram Ravikumar
2012 Applied Nanoscience  
Malaria is the most important parasitic disease, leading to annual death of about one million people and the Plasmodium falciparum develops resistant to well-established antimalarial drugs. The newest antiplasmodial drug from metal oxide nanoparticles helps in addressing this problem. Commercial nanoparticles such as Fe 3 O 4 , MgO, ZrO 2 , Al 2 O 3 and CeO 2 coated with PDDS and all the coated and non-coated nanoparticles were screened for antiplasmodial activity against P. falciparum. The Al
more » ... falciparum. The Al 2 O 3 nanoparticles (71.42 ± 0.49 lg ml -1 ) showed minimum level of IC 50 value and followed by MgO (72.33 ± 0.37 lg ml -1 ) and Fe 3 O 4 nanoparticles (77.23 ± 0.42 lg ml -1 ). The PDDS-Fe 3 O 4 showed minimum level of IC 50 value (48.66 ± 0.45 lg ml -1 ), followed by PDDS-MgO (60.28 ± 0.42 lg ml -1 ) and PDDS-CeO 2 (67.06 ± 0.61 lg ml -1 ). The PDDS-coated metal oxide nanoparticles showed superior antiplasmodial activity than the non-PDDS-coated metal oxide nanoparticles. Statistical analysis reveals that, significant in vitro antiplasmodial activity (P \ 0.05) was observed between the concentrations and time of exposure. The chemical injury to erythrocytes showed no morphological changes in erythrocytes by the nanoparticles after 48 h of incubation. It is concluded from the present study that, the PDDS-Fe 3 O 4 showed good antiplasmodial activity and it might be used for the development of antiplasmodial drugs.
doi:10.1007/s13204-012-0130-8 fatcat:og5usi5usrh4ref3qlepe7k5xm