The purpose of this study was to investigate how HRM practices improve retention of employees in the perspective of investment in public health organizations in Benishangul Gumuz Regional State, Ethiopia. Literature showed that organizations under study were suffering from weak practices of human resources, consideration of employees as physical assets, lack of human resource professionals at necessary position and weak retention strategies. The study adopted a mixed method of research design

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... d targeted 1514 health professionals from 35 public health facilities. Respondents from health centers and hospitals were selected using multistage sampling and as a result 317 respondents were randomly selected from 17 health organizations. Semi structured interview was administered to 8 Human resource administrators and heads of Bureau, zone offices and hospital. Questionnaire was checked validity and reliability of Cronbach"s alpha .979 which was consistent with the final instrument alpha value of .969. The response rate was found to be (93.7%). Qualitative data from interview were analyzed by using narrative method. The finding showed that the HRM practices were found to be weak and employees are most likely intended to find new jobs. Organizations were recommended to give attention to the people working in HR department; health organizations should be free of politics and political parties and there should be continuous monitoring and follow up of HRM practices at each public health institution in order to track problems at their infant level and take remedial actions.