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Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain
Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell typeanddoi:10.5483/bmbrep.2020.53.11.204 fatcat:htdnnrafqzbfhnwi4vjcmmzf7i