Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer

Y. Ding, L.N. Li
2015 Genetics and Molecular Research  
We performed a study to evaluate X-ray repair crosscomplementing protein 4 (XRCC4) gene polymorphisms and the development of pancreatic cancer. A case-control study including 206 patients with newly diagnosed primary pancreatic cancer and 412 controls was performed between January 2011 and October 2013 in a Chinese population. Genotypes of XRCC4 rs1805377, rs2075685, rs2075686 and rs1056503 were determined using polymerase chain reaction combined with a restriction fragment length polymorphism
more » ... ssay. Compared with controls, pancreatic cancer patients were more likely to have a higher body mass index, family history of cancer, and a habit of alcohol drinking compared with controls (P < 0.05). Logistic regression analysis showed that individuals carrying the TT genotype of XRCC4 rs2075685 had an increased risk of pancreatic cancer compared to those with the GG genotype, with an odds ratio (95% confidence interval) of 1. 88 (1.15-3.08). Our results suggest that the 9627 DNA repair genes and pancreatic cancer ©FUNPEC-RP Genetics and Molecular Research 14 (3): 9626-9632 (2015) XRCC4 rs2075685 polymorphism could influence the susceptibility to pancreatic cancer in a Chinese population.
doi:10.4238/2015.august.14.25 pmid:26345895 fatcat:zadoyqit5rfzfbm3dudrwx5vhi