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FGF18 inhibits MC3T3-E1 cell osteogenic differentiation via the ERK signaling pathway
Molecular Medicine Reports
Fibroblast growth factor (FGF) 18 is a member of the FGF family and serves a key role in skeletal growth and development. The present study investigated the effect of FGF18 on pre-osteoblast MC3T3-E1 cells and the signaling pathways involved by performing an alkaline phosphatase (ALP) assay and reverse transcription-quantitative polymerase chain reaction. MC3T3-E1 cells incubated in a culture medium supplemented with FGF18 exhibited increased viability when compared with the untreated controldoi:10.3892/mmr.2017.7088 pmid:28765932 fatcat:eejtlhlfsbfdxpvorlonfdfw2e