Behavior and interaction imaging at 9 months of age predict autism/intellectual disability in high-risk infants with West syndrome

Lisa Ouss, Giuseppe Palestra, Catherine Saint-Georges, Marluce Leitgel Gille, Mohamed Afshar, Hugues Pellerin, Kevin Bailly, Mohamed Chetouani, Laurence Robel, Bernard Golse, Rima Nabbout, Isabelle Desguerre (+2 others)
2020 Translational Psychiatry  
Automated behavior analysis are promising tools to overcome current assessment limitations in psychiatry. At 9 months of age, we recorded 32 infants with West syndrome (WS) and 19 typically developing (TD) controls during a standardized mother-infant interaction. We computed infant hand movements (HM), speech turn taking of both partners (vocalization, pause, silences, overlap) and motherese. Then, we assessed whether multimodal social signals and interactional synchrony at 9 months could
more » ... t outcomes (autism spectrum disorder (ASD) and intellectual disability (ID)) of infants with WS at 4 years. At follow-up, 10 infants developed ASD/ID (WS+). The best machine learning reached 76.47% accuracy classifying WS vs. TD and 81.25% accuracy classifying WS+ vs. WS-. The 10 best features to distinguish WS+ and WS- included a combination of infant vocalizations and HM features combined with synchrony vocalization features. These data indicate that behavioral and interaction imaging was able to predict ASD/ID in high-risk children with WS.
doi:10.1038/s41398-020-0743-8 pmid:32066713 fatcat:cxewktearnfnplpcaczhg5uici