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Diallyl disulfide (DADS), one of the major organosulfur compounds of garlic, is recognized as a group of potential chemopreventive compounds. In this study, we examines the early signaling effects of DADS on human colorectal cancer cells SW480 loaded with Ca 2? -sensitive dye fura-2. It was found that DADS caused an immediate and sustained rise of [Ca 2? ] i in a concentration-dependent manner (EC 50 = 232 lM). DADS also induced a [Ca 2? ] i elevation when extracellular Ca 2? was removed, butdoi:10.1007/s00204-011-0748-4 pmid:21879349 fatcat:vioxfskl3vaadf5tzix7luhkhe