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Prophylaxis and Treatment of Invasive Fungal Diseases in Allogeneic Stem Cell Transplantation: Results of a Consensus Process by Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

Corrado Girmenia, Giovanni Barosi, Franco Aversa, Andrea Bacigalupo, Tiziano Barbui, Donatella Baronciani, Alberto Bosi, Anna Candoni, Anna Locasciulli, Franco Locatelli, Francesco Menichetti, Maurizio Musso (+2 others)
2009 Clinical Infectious Diseases  

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In recent years, prospective studies have been conducted to assess the role of prophylaxis and treatment of invasive fungal diseases (IFD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although results of these studies have been encouraging, they have been unable to generate a consensus for optimal prophylaxis and treatment of IFD in the complex scenario of allo-HSCT. A consensus process was undertaken to describe and evaluate current information and practice regarding key
more » ... uestions on IFD management in allo-HSCT recipients; these questions were selected according to the criterion of relevance by group discussion. The Panel produced recommendations for risk stratification, prophylaxis, monitoring, and therapy of IFD and identified top priority issues for further investigation. The definition of the level of risk for IFD associated with the various types and phases of transplantation and the implementation of surveillance and diagnostic strategies are the critical determinants of the antifungal prophylactic and therapeutic approach for allo-HSCT recipients. Invasive fungal diseases (IFDs) represent a leading cause of morbidity and mortality among allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] . A cohort-retrospective study, conducted during the period 1999-2003 at 11 Italian transplantation centers showed a 7.8% incidence (98 patients) of proven or prob-
doi:10.1086/605665 pmid:19772390 fatcat:vzcunjdtuvgyhitqujqggssgkm
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Corrado Girmenia, Giovanni Barosi, Franco Aversa, Andrea Bacigalupo, Tiziano Barbui, Donatella Baronciani, Alberto Bosi, Anna Candoni, Anna Locasciulli, Franco Locatelli, Francesco Menichetti, Maurizio Musso, Claudio Viscoli, Alessandro Rambaldi. "Prophylaxis and Treatment of Invasive Fungal Diseases in Allogeneic Stem Cell Transplantation: Results of a Consensus Process by Gruppo Italiano Trapianto di Midollo Osseo (GITMO)." Clinical Infectious Diseases 49.8 (2009) 1226-1236