1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

Lars-Oliver Klotz, Xiaoqing Hou, Claus Jacob
2014 Molecules  
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor
more » ... lation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Generation of reactive oxygen species and modulation of redox signaling are properties of naphthoquinones that render them interesting leads for the development of novel compounds of potential use in various therapeutic settings.
doi:10.3390/molecules190914902 pmid:25232709 fatcat:l4cygucylnh37krk3arcfmfhyq