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Molecular Screening of PROKR2 Gene in Girls with very early Idiopathic Central Precocious Puberty
[post]
2020
unpublished
Background Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017 a first case of central precocious puberty (CPP) caused by heterozygous gain of function mutation in PROKR2 was described in a 3.5-year‐old girl. No other cases have been reported yet. This study performs a molecular screening in girls with "early" onset CPP (breast budding before 6 years of age) in order to identify possible alterations in PROKR2.Methods
doi:10.21203/rs.3.rs-41264/v1
fatcat:oean6gvmrfdk5cz6r4lpwbct6y