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Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template
Natural and synthetic biological networks must function reliably in the face of fluctuating stoichiometry of their molecular components. These fluctuations are caused in part by changes in relative expression efficiency and the DNA template amount of the network-coding genes. Gene product levels could potentially be decoupled from these changes via built-in adaptation mechanisms, thereby boosting network reliability. Here, we show that a mechanism based on an incoherent feedforward motifdoi:10.3929/ethz-b-000039302 fatcat:kyoost5jr5eebg4erm63eqgsty