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Transporters shuttle molecules across cell membranes by alternating among distinct conformational states. Fundamental questions remain about how transporters transition between states and how such structural rearrangements regulate substrate translocation. Here we capture the translocation process by crystallography and unguided molecular dynamics simulations, providing an atomic-level description of alternating access transport. Simulations of a SWEET-family transporter initiated from andoi:10.1016/j.cell.2017.03.010 pmid:28340354 pmcid:PMC5557413 fatcat:d2dongtdgvdvzpfyig7sgujk3m