Corticosteroid treatment for community-acquired pneumonia--the STEP trial: study protocol for a randomized controlled trial [article]

Mirjam Christ-Crain, Philip Tarr, Roland Bingisser, Isabelle Suter-Widmer, Hervé Duplain, Claudine A Blum, Nicole Nigro, Bettina Winzeler, Dieter Burki, Beat Mueller, Sebastian Wirz, Matthias Briel (+7 others)
Community-acquired pneumonia (CAP) is the third-leading infectious cause of death worldwide. The standard treatment of CAP has not changed for the past fifty years and its mortality and morbidity remain high despite adequate antimicrobial treatment. Systemic corticosteroids have anti-inflammatory effects and are therefore discussed as adjunct treatment for CAP. Available studies show controversial results, and the question about benefits and harms of adjunct corticosteroid therapy has not been
more » ... onclusively resolved, particularly in the non-critical care setting.
doi:10.7892/boris.65184 fatcat:pjmjuybikzan7nflvrfztm3hga