Role of Measurement of Reactive Oxygen Species in Semen Sample of Patients with Male Factor Infertility and Treatment with Antioxidants in Patients with High ROS Levels

Satyabrato Chatterjee, Pankaj Talwar
2019 International Journal of Contemporary Medical Research [IJCMR]  
It is a known fact that human sperms, produce reactive oxygen species in small amounts, which is useful for normal functioning of the sperm mainly sperm oocyte interaction acrosome reaction and capacitation. Recent research has shown that this ROS in increased amounts is a cause of male infertility. Material and methods: It is a prospective control trial to determine the abnormal pattern of reactive oxygen species in semen sample of patients with male factor infertility and to determine the
more » ... o determine the effects of antioxidants in semen sample of patients with high ROS in semen sample. 150 patients were selected who were undergoing IVF treatment. Patients were divided into three groups according to the severity of abnormality in the semen analysis. The ROS levels of all the patients were measured and compared with 50 normal fertile donors. The patients whose ROS levels was found to be high were then given antioxidants for 2 months and their ROS levels in semen measured for improvement. Results: The ROS levels were significantly high in all the three groups compared to fertile donors. The patients with high R0S levels were then treated with antioxidants and it was seen that all the three groups had significant improvement in their ROS levels. Conclusion: So, to conclude it is hence proved by my study that ROS level measurement is useful for patients with male factor infertility and the use of antioxidants significantly helps in reducing ROS levels in semen. How to cite this article: Satyabrato Chatterjee, Pankaj Talwar. Role of measurement of reactive oxygen species in semen sample of patients with male factor infertility and treatment with antioxidants in patients with high ROS levels.
doi:10.21276/ijcmr.2019.6.2.30 fatcat:3h22ghhjjvbqvmh7asxxyw36nq