Integrative approaches for finding modular structure in biological networks

Koyel Mitra, Anne-Ruxandra Carvunis, Sanath Kumar Ramesh, Trey Ideker
2013 Nature reviews genetics  
An extreme case of negative genetic epistasis in which the mutation of two genes in combination, but not individually, causes a lethal phenotype. Abstract | A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with
more » ... molecular profiles to identify sets of molecules and interactions that participate in a common biological function -that is, 'modules'. Here, we classify such integrative approaches into four broad categories, describe their bioinformatic principles and review their applications.
doi:10.1038/nrg3552 pmid:24045689 pmcid:PMC3940161 fatcat:4b5rihmvyzefrm3om7vzanvqc4