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Integrative approaches for finding modular structure in biological networks
2013
Nature reviews genetics
An extreme case of negative genetic epistasis in which the mutation of two genes in combination, but not individually, causes a lethal phenotype. Abstract | A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with
doi:10.1038/nrg3552
pmid:24045689
pmcid:PMC3940161
fatcat:4b5rihmvyzefrm3om7vzanvqc4