A Review on the Reconstruction of Articular Cartilage Using Collagen Scaffolds

Horea Benea, Gheorghe Tomoaia, Olga Soritau, Roxana-Diana Pasca
2016 Romanian Biotechnological Letters   unpublished
The reconstruction of articular cartilage has a great importance since more and more people are affected by osteoarticular diseases. Among these, osteoarthritis occupies a central place and affects mostly mature patients. Cartilage contains a significant quantity of collagen, so a first step in osteochondral reconstruction is represented by the developing of new materials based on collagen that can be used as implants in hard tissue engineering. There are many possibilities to construct
more » ... o construct biomaterials containing collagen, depending on the purpose. The collagen scaffolds prepared must have a series of characteristics such as biocompatibility and osseointegration. Before use, those scaffolds have to be well chemically characterized and tested in vitro experiments on cell cultures (chondrocytes are responsible for the cartilage regeneration) and in vivo studies on animal models (especially rats). The most important ways to prepare collagen scaffolds that can be used in the articular cartilage reconstruction are reviewed here.