Differential Endothelial Function According to the Presence of Restenosis in Patients Having Undergone Percutaneous Transluminal Coronary Angioplasty

Ki Rack Park, Jang Ho Bae
2001 Korean Circulation Journal  
and Objectives We undertook this study to determine whether there is any difference in endothelial function according to the presence of restenosis in patients who had undergone percutaneous transluminal coronary angioplasty PTCA , although it is well known that endothelial dysfunction is present in patients with coronary artery disease. Subjects and Methods The study population comprised 39 patients mean age 61 years old, male 30 patients who underwent PTCA a mean 12 months before follow-up
more » ... onary angiogram CAG . We measured the flow-mediated brachial artery dilation FMD using high-resolution ultrasound 1 day before taking the follow-up CAG in an overnight fasting state. We also analyzed the risk factors of atherosclerosis, lipid and glucose levels, the presence of chest pain, and the types of drug taken by patients according to the presence of restenosis. Results FMD was significantly lower in patients with restenosis n 19 than without restenosis 7.5 3.7% vs 10.2 2.5%, p 0.013 . However, there were no significant differences in other variables according to the presence of restenosis. Conclusion Endothelial dysfunction was more pronounced in patients with restenosis than without restenosis following PTCA. However, we do not yet know whether the severity of endothelial dysfunction is a predictor for restenosis as the FMD was taken just prior to the follow-up coronary angiogram.
doi:10.4070/kcj.2001.31.11.1117 fatcat:xyuuwqe7zzdmrmoqyyka6qwdmm