LIPID PROFILE, PLASMA FIBRINOGEN, AND PLATELET COUNT AS MARKERS OF CARDIO VASCULAR DISEASE IN SMOKERS DUE TO FREE RADICAL GENERATION

N Kannan, R Aravind Kumar, Ramaprabha P, Satish Kumar M, Ivvala Anand Shaker
2013 Journal of Pharmaceutical and Scientific Innovation  
Cigarette smoking & tobacco chewing are risk factors not only for oral and lung tumours but also for the development of systemic disorders like atherosclerosis, coronary artery disease and peripheral vascular disease. This study was undertaken to evaluate the lipid profile, plasma fibrinogen and platelet count in male smokers, compared with healthy non smokers in rural area of south India, Out of 100 male healthy volunteers, 50 members were healthy smokers and 50 healthy non smokers, subjects
more » ... smokers, subjects were divided in both groups in age around 30 to 45yrs, with no past history of diabetes mellitus, hypertension, hepatic disorders and were neither on anti hypertensive, lipid lowering drugs were included in the study. Lipid profile, plasma fibrinogen and platelet count were analyzed by standard methods. Our results showed mean platelet count for smokers is 2, 86,345per mm 3 and for non-smokers 2, 04,484.6per mm 3 . The mean plasma fibrinogen concentration for smokers is 3.48gm/dl and for non smokers is 3.12gm/dl. The platelet count and plasma fibrinogen concentration shows a higher value for smokers when compared to non-smokers. This is statistically significant. The mean total cholesterol level for smokers (186±30.10) mg/dl and non smokers (166.3±24.26) mg/dl and the mean triglyceride level for smokers (175±59.43) mg/dl and non smokers (132.09±+33.80) mg/dl are also statistically significant. The mean HDL level for smokers (40.4±4.13) mg/dl and for non smokers (44.68±4.13) mg/dl, the mean LDL level for smokers (105.8±28.16) mg/dl and non smokers (89.68±16.50) mg/dl and the mean VLDL level for smokers (28.4± 8.16) mg/dl and non smokers (14.3.±3.2) mg/dl indicate that the Lipid profile also is statistically significant between the two groups. We concluded that there is an elevated lipid profile; plasma fibrinogen and platelet count in smokers when compared to non smokers, which shows that smokers have high risk of prevalence of cardiovascular and vessel wall diseases.
doi:10.7897/2277-4572.02335 fatcat:mbop6v5nobhgfalqcj2p7eunqq