Utility of routine haematological parameters and infectious biomarkers to assess the disease severity in COVID-19 positive patients, analysis and early trend from India [post]

Pomilla Singh, Alok Kumar, Shashank Singh, Anjali Kelkar, Preeti Doshi, RC Nimbargi, NS Mani
2020 unpublished
Background and Objective- India has emerged as fifth worst hit nation by novel Corona virus pandemics in terms of total number of cases. Our literature on clinicopathological, hematopathological characterstics and trend is still miniscule. The study was conducted to assess utility of haematological parameters and infection biomarkers in identifying disease severity. Method- The test results for complete blood counts, Coagulation screen and inflammatory markers of covid 19 positive patients were
more » ... itive patients were recorded and analysed based on their admission to Intensive care units, High Dependency Units or Ward. Those parameters with significant differences between the groups werewere assessed by receiver operating curve and the best screening cut-off was selected. Results- 100 adults were analysed, area under the curve for total leukocyte count, Absolute neutrophil count, Neutrophil-to-Lymphocyte ratio was found >0.800, with p<0.05.The best cut off value obtained for TLC was 8100/cmm, with sensitivity and specificity of 91% and 62.5%; ANC – 6739/cmm, with 91.7% and 75% respectively; NLR - 6.9 with sensitivity and specificity 91.7% and 87.5% respectively. Haematological parameters of 33 paediatric patients studied separately and were well within normal physiological limits. Interpretation and conclusion- study suggests that in adults, using TLC, ANC and NLR, obtained from the basic preliminary workup may segregate patients requiring intensive care at the time of admission enabling risk stratification and guide intervention.
doi:10.21203/rs.3.rs-40378/v1 fatcat:6xoixrrdobcq7l5vkqra4asymi