The effect of NAFLD (non-alcoholic fatty liver disease) on long-term outcome of chronic hepatitis B in Iranian patients

Arezoo Estakhri, Ali Akbari Sari, Sahar Naz Nedjat, Marym Rohban, Naser Rakhshani, Seyed Mohammad Tavangar, Reza Malekzadeh, Ghodrat Montazeri
2012 Open Journal of Gastroenterology  
The influence of Non-Alcoholic Fatty Liver Disease on the outcome of chronic hepatitis B disease, including viral, biochemical and histologic characteristics, in Iranian patients is not yet fully understood. Aim: To evaluate the effect of Non-Alcoholic Fatty Liver Disease (NAFLD) on long-term histologycal, biochemical and viral outcome of chronic hepatictis B in Iranian patients. Methods: We retrospectively evaluated 94 "e Ag" negative chronic hepatitis B patients (with NAFLD: 44, without
more » ... : 44, without NAFLD: 50). Non-Alcoholic Fatty Liver Disease was diagnosed based on liver biopsy according to Kleiner classification. Liver biopsy was done for all patients. Serological and biochemical variables were evaluated with repeated measure analysis. Results: Non-Alcoholic Fatty Liver Disease (NAFLD) was present in 47% of the patients (44 out of 94 patients). In the NAFLD group, increase in AST, ALT, stage (P = 0.002), grade, and total score of liver biopsy were independently related to non-alcoholic fatty liver disease, while HBV-DNA viral load did not correlate with the presence of a fatty liver. Conclusion: Abnormalities of liver enzymes and liver histopathology are more prevalent in concurrent chronic hepatitis B and Non-Alcoholic Fatty Liver Disease (NAFLD).
doi:10.4236/ojgas.2012.21004 fatcat:t2traf2cbveuxamomd5phhbamu